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DiscoverX BTK (E41K), active 14-773-K
品牌:Eurofins DiscoverX
货号:14-773-K
规格:14-773-K
货期:Eurofins DiscoverX

品牌:DiscoverX 品名:BTK (E41K), active 货号:14-773-K 规格:Bulk

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品牌:DiscoverX
品名:BTK (E41K), active
货号:14-773-K
规格:Bulk 

简要说明:

BTK (E41K), active

N-terminal 6His-tagged recombinant, human full length BTK. Specific mutations within the pleckstrin homology (PH) domain of BTK results in human X-linked aγglobulinemia (XLA). The E41K substitution, identified through random mutagenesis, is a PH domain gain-of-function mutation that has been shown to be associated with increased membrane localization and tyrosine phosphorylation of BTK. Using animal models, this mutation has been shown to arrest the development of immature B cells and to act as a tumour suppressor in B-cell linker protein (BLNK/SLP-65)-deficient hosts. (Li, .et al., Immunity,(1995);2:451-460 and Baraldi, E., et al., Structure,(1999);7:449-460).

产品介绍:

Target
BTK
Expression System
Expressed by baculovirus in Sf21 insect cells
Application
Kinase Assay
Molecular Weight
78.4 kDa
Accession Number
NM_000061
Species
Human
Tag
6His
Purification Method
Ni2+/NTA-agarose
Storage
6 months at -70°C
Bulk Sizes
Inquire



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