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DiscoverX c-Kit (V654A), active 14-733-K
品牌:Eurofins DiscoverX
货号:14-733-K
规格:14-733-K
货期:DiscoverX

品牌:DiscoverX 品名:c-Kit (V654A), active 货号:14-733-K 规格:Bulk

商品详情 参考文献 相关资料
品牌:DiscoverX
品名:c-Kit (V654A), active
货号:14-733-K   
规格:Bulk 

简要说明:

c-Kit (V654A), active

N-terminal GST-tagged recombinant, human c-Kit amino acids 544 - end containing the V654A mutation. Co-ordinates encompass the cytoplasmic domain (544-976) according in Swiss Prot P10721. V654A is an acquired resistance mutation which has been found in patients with gastrointestinal stromal tumours (GISTs) undergoing treatment with Imatinib. The V654A mutation is strongly correlated with imatinib resistance and rapid progession of GISTs. (Chen LL et al., Cancer Research, (2004); 64:5913-5919).


产品介绍:

Target
c-Kit
Expression System
Expressed by baculovirus in Sf21 insect cells
Application
Kinase Assay
Molecular Weight
76.7 kDa
Accession Number
NM_000222.2; NM_001093772.1
Species
Human
Tag
GST
Purity
Purity 99% by SDS-PAGE and Coomassie blue staining.
Purification Method
Glutathione agarose affinity chromatography
Storage
6 months at -70°C
Bulk Sizes
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