Catalogue number
PRO-2093
Synonyms
Ceramide-1-Phosphate Transfer Protein, Glycolipid
Transfer Protein Domain-Containing Protein 1, Glycolipid Transfer Protein
Domain Containing 1, GLTP Domain-Containing Protein 1, GLTPD1, GLTPD1, Ceramide-1-phosphate
transfer protein, CPTP.
Introduction
Glycolipid Transfer Protein Domain Containing 1 (GLTPD1) belongs to the
GLTP family. GLTPD1 mediates the intracellular transfer of ceramide-1-phosphate
between organelle membranes and the cell membrane. GLTPD1 is essential for
normal structure of the Golgi stacks. In addition, GLTPD1 is able to bind
phosphoceramides with a diversity of aliphatic chains, however GLTPD1 has a
preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains.
Moreover, GLTPD1 is inefficient with phosphoceramides which contains lignoceryl
(C24:0). GLTPD1 participates in the regulation of the cellular levels of
ceramide-1-phosphate, and in that way contributes to the regulation of
phospholipase PLA2G4A activity and the release of arachidonic acid.
Description
GLTPD1 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 237 amino acids (1-214 a.a) and
having a molecular mass of 26.8kDa.
GLTPD1 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
GLTPD1 protein solution (0.25mg/ml) containing Phosphate
buffered saline (pH7.4), 50% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMDDSETG FNLKVVLVSF KQCLDEKEEV LLDPYIASWK GLVRFLNSLG
TIFSFISKDV VSKLRIMERL RGGPQSEHYR SLQAMVAHEL SNRLVDLERR SHHPESGCRT VLRLHRALHW
LQLFLEGLRT SPEDARTSAL CADSYNASLA AYHPWVVRRA
VTVAFCTLPT REVFLEAMNV GPPEQAVQML GEALPFIQRV YNVSQKLYAE
HSLLDLP.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
