Catalogue number
PRO-754
Synonyms
Antioxidant protein 1, ATX1, HAH1, Copper transport protein ATOX1, Metal transport protein ATX1, ATOX1, MGC138453, MGC138455.
Introduction
ATOX1 is a metal transport protein that is part of the ATX1 family. ATOX1 is a copper chaperone that takes part in cellular antioxidant defense and can bind and deliver cytosolic copper to the copper ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. ATOX1 plays a role as an antioxidant against superoxide and hydrogen peroxide, and consequently, takes an important part in cancer carcinogenesis. Because of ATOX1 cytogenetic location, the gene can be a good a candidate gene for 5q-syndrome.
Description
ATOX1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids (1-68 a.a.) and having a molecular mass of 9.5kDa. ATOX1 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile filtered colorless solution.
Formulation
ATOX1 solution containing 20mM Tris pH-8, 1mM DTT and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze thaw cycles.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LLATLKKTGK TVSYLGLE.
Safety Data Sheet
Purity
Greater than 95% as determined by SDS-PAGE.
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
