Vaccine Carrier Proteins and Adjuvants Large inactivated toxins such as tetanus toxoid, diphtheria toxoid and diphtheria CRM197 are used as carriers in vaccines to develop strong immune responses. Conjugate vaccines rely on these immunogenic molecules to stimulate long-lasting immunity to attached polysaccharides or peptides. List Labs provides, for purchase, formaldehyde inactivated native toxins such as tetanus toxoid and diphtheria toxoid, as well as the natural mutant diphtheria toxin, CRM197, all potential carrier proteins and vaccine adjuvants. Recently List Labs has produced genetically altered pertussis toxin which retains some toxin activity and may be used as a carrier protein/vaccine adjuvant. List Labs vaccine carrier proteins and adjuvants are provided for research use only; however, GMP material may be produced on a contract basis. Contact us if you are interested in GMP production or in using toxoids of other native toxins as carriers or vaccine adjuvants. Our Citations include information referencing the use of vaccine carrier proteins in research. Our Support Portal provides technical information on our vaccine carrier products. Visit our blog to learn more about what we do. Our Vaccine Carrier Proteins and Vaccine Adjuvants Include: Tetanus Toxoid made from native tetanus toxin, produced in Clostridium tetani Cholera Toxin B Subunit made from Vibrio cholerae Diphtheria Toxoid CRM197, a natural genetically inactive diphtheria toxin (mutant) produced in the native host, Corynebacterium diphtheriae Adenylate Cyclase Mutant, Recombinant from Bordetella pertussis Pertussis Toxin Mutant, activity decreased by genetic alteration of pertussis toxin, produced in Bordetella bronchiseptica Selected Lipopolysaccharides: #400, #401, #421, #423, #433, and #434 For a list of all of the toxoids produced by List Labs, follow the link to Toxoids. Cholera Toxin B Subunit (Choleragenoid)
from Vibrio cholerae in Low Salt Cholera Toxin B Subunit (Choleragenoid) from Vibrio cholerae in Low Salt #104 Diphtheria Toxin CRM₁₉₇, Mutant Diphtheria Toxin CRM197, Mutant #149A Diphtheria Toxoid, from Corynebacterium diphtheriae Diphtheria Toxoid, from Corynebacterium diphtheriae #151 HPT™ LPS, highly purified from Bordetella
pertussis 165 HPT™ LPS, highly purified from Bordetella pertussis 165 #400 LIPID A monophosphoryl
from Salmonella minnesota R595 LIPID A monophosphoryl from Salmonella minnesota R595 #401 LIST™ HPT™ from Escherichia coli O113 LIST™ HPT™ from Escherichia coli O113 #433 Pertussis Toxin Mutant Pertussis Toxin Mutant #184 Tetanus Toxoid from Clostridium tetani Tetanus Toxoid from Clostridium tetani #191A, #191B ULTRA PURE LPS from Escherichia coli O111:B4 ULTRA PURE LPS from Escherichia coli O111:B4 #421 ULTRA PURE LPS from Escherichia coli O55:B5 ULTRA PURE LPS from Escherichia coli O55:B5 #423 ULTRA PURE LPS from Salmonella minnesota R595 (Re) ULTRA PURE LPS from Salmonella minnesota R595 (Re) ULTRA PURE LPS from Salmonella minnesota R595 (Re) #434