Biological Activity:SMER3 is a potent and selective a yeast SCF family E3 ubiquitin ligase inhibitor, also a small-molecule enhancers of rapamycin. It inhibits SCF(Met30), but not the closely related SCF(Cdc4). SMER3 can diminish binding of the F-box subunit Met30 to the SCF core complex in cell, induces the expression of MET genes and blocks cell proliferation.How to Use:In vitro: SMER3 was used at 10-20 µM final concentration in various in vitro assays.In vivo: n/aReference:
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