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Smartox Biotechnology

  

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Smartox Biotechnology

离子通道研究用多肽毒素的专业化生产商

Smartox Biotechnology是全球唯壹一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

Smartox Biotechnology2009年由来自Grenoble神经科学研究所(Grenoble Institute of Neuroscience)Michel de waard博士创立,Smartox Biotechnology专门研究动物毒液,制作合成多种毒液中的多肽成分(常称为毒素)。De Waard博士研究离子通道与毒素多肽的关系,尤其是鉴定、开发毒素多肽作为治疗性分子或细胞穿透肽(cell penetrating peptides, CPP)。其研究团队在毒液分离,药理性活性肽鉴定、富半胱氨酸肽定性、制作和优化等方面具有独特、丰富的经验。2010年,Smartox Biotechnolgy被法国研究部(Ministry of Research)授予“新兴企业OSEO(OSEO prize for emerging businesses)”。

总之,Smartox Biotechnology提供一系列高质量、具开创价值的多肽毒素。这些化合物在离子通道 研究中具有高的亲和性和选择性,是相应领域科学研究理想的生物毒素提供商和贴心的合作伙伴。

 Smartox Biotechnology毒素产品包括:

钠离子通道(Sodium channel)

Toxin name

Catalog #

Target

Phrixotoxin-3

13PHX003

Selective blocker of Nav1.2

µ-conotoxin GIIIB

CON020

Selective blocker of Nav1.4

µ-conotoxin CnIIIC

CON021

Selective blocker of Nav1.4

μ-conotoxin PIIIA

08CON006

Selective blocker of Nav1.4

Jingzhaotoxin-III

12JZH003

Selective blocker of Nav1.5

ProTx-II

07PTX002

Selective blocker of Nav1.7

ProTx-II Biotin

12PTB002

Selective blocker of Nav1.7

ProTx-I

12PTX001

Blocker of Nav1.8, Nav1.2, Nav1.5, Nav1.7

Huwentoxin-I

07HWT001

Blocker of TTX-S

Huwentoxin-IV

08HWT002

Blocker of TTX-S

Hainantoxin-III

13HTX003

Blocker of TTX-S

Hainantoxin-IV

12HTX001

Blocker of TTX-S

GsAF-I

12GSF001

Blocker of TTX-S

GsAF-II

12GSF002

Blocker of TTX-S

 

钾离子通道(Potassium channel)

KCa channels

Toxin name

Catalog #

Target

Description

Apamin

08APA001

SK1, SK2, SK3

 

Charybdotoxin

11CHA001

KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6

 

Iberiotoxin

12IBX001

KCa1.1

 

Leiurotoxin 1 (Scyllatoxin)

10LEI001

SK1, SK2, SK3

 

Tamapin

10TAM001

SK1, SK2, SK3

 

Kaliotoxin-1

08KTX002

BK, Kv1.1, Kv1.2, Kv1.3

 
 

Kv channels

ShK

08SHK001

Kv1.3, Kv1.1, Kv1.4, Kv1.6

 

TMR-ShK

SAT001

Kv1.3, Kv1.1

 

Margatoxin

08MAG001

Kv1.3

 

(Dap22)-ShK

13SHD001

Kv1.3

 

ADWX-1

13ADW001

Kv1.3

 

HsTx1

08NEU001

Kv1.3, Kv1.2

 

Agitoxin-2

13AGI002

Kv1.3, Kv1.1

 

Maurotoxin

08MAR001

Kv1.2, KCa3.1

 

Guangxitoxin 1E

11GUA002

Kv2.1, Kv2.2

 

Stromatoxin 1 NEW

SCT01

Kv2.1, Kv2.2

 

Kaliotoxin-1

08KTX002

BK, Kv1.1, Kv1.2, Kv1.3

 

Charybdotoxin

11CHA001

KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6

 

Phrixotoxin-2

PHX002

Kv4.2, Kv4.3

 

AmmTx3 NEW

AMX001

A-type potassium channels

 
 

Inwardly rectifying potassium channels

TertiapinQ

08TER001

Kir1.1, Kir3.1/3.4, Kir3.1/3.2-KCa1.1

 
 

hERG/Kv11.1

BeKm-1

13BEK001

ERG1

 

 

钙离子通道(Calcium channel)

High voltage-gated Ca2+ channels

Toxin name

Catalog#

Target

Description

ω-agatoxin IVA

11AGA001

P/Qtype

 

ω-Conotoxin MVIIC

08CON002

P/Qtype, N-type

 

ω-Conotoxin MVIIA

08CON001

N-type

 

ω-Conotoxin GVIA

08CON003

N-type

 

ω-Conotoxin SO3

08CON013

N-type

 

Huwentoxin I

07HWT001

N-type

 

ProTx-II

07PTX002

T-type, L-type

 
 

Intermediate voltage-gated Ca2+ channels

SNX482

08SNX002

R-type

 
 

Low voltage-gated Ca2+ channels

ProTx-I

12PTX001

T-type

 

ProTx-II

07PTX002

T-type, L-type

 
 

Ryanodine receptors

Maurocalcine

07PAU001

Ryr1

 

 

氯离子通道(Chloride channel)

Toxin name

Catalog #

Target

Description

Chlorotoxin

08CHL001

Blocker of small conductance Cl- channels

 

GaTx1

13GTX001

Selective blocker of CFTR channel

 

GaTx2

10GTX002

Selective blocker of ClC-2 channel

 

 

乙酰胆碱受体(Acetylcholine receptor)

Toxin name

Catalog #

Target

Description

α-conotoxin PeIA

13CON017

α9α10, α3β2 subunits

 

αC-Conotoxin PrXA

13CON016

α1/β1/ε/δ, α1/β1/γ/δ subunits

 

Waglerin-1

12WAG001

MusclenAChR

 

α-conotoxin MI

08CON012

α1/δsubunits

 

α-conotoxin GI

08CON005

α/δsite

 

α-conotoxin IMI

08CON011

α7 homomeric nAChR

 

α-conotoxin GID

CON019

Blocker of α3β2, α7 and α4β2 nAChRs

 

 

N-甲基-D-天冬氨酸NR2B (NMDA, NR2B containing N-methyl-D-aspartate)

Conantokin-G选择性、特异性抑制含NR2BNMDARConantokin-G能剂量依赖性抑制Ca2+内流,抑制NMDA诱导的兴奋性中毒效应。研究表明,在小鼠皮层神经元,Conantokin-G阻滞NMDA引发的电流信号的IC50值为480 nM

 

酸敏感离子通道(ASIC channel, Acid-Sensing Ion Channel)

Toxin name

Catalog #

Target

Description

APETx2

07APE002

Selective blocker of ASIC3

 

Psalmotoxin1/PcTx1

13PCT001

Selective blocker of ASIC1a

 

Ugr9-1

13UGR001

Blocker of ASIC3

 

 

瞬时受体电位(TRP channel, transient receptor potential)

Toxin name

Catalog #

Target

Description

GsMTx4

08GSM001

TRPC, TRPA

 

Vanillotoxin3

10VAN003

Activator of TRPV1

 

ProTx-I

12PTX001

Antagonist of TRPA1

 

 

嘌呤能通道(Purinergic channel)

Purotoxin-1

选择性抑制P2X3受体。100 nM Purotoxin-1 (PT-1)选择性抑制P2X3受体通道,在大鼠DRG神经元上,使用膜片钳实验表明:PT-1对电压门控通道和TRPV1均无抑制效应。10 µM ATP100 µM α,β Methylene-ATP浓度下Purotoxin-1P2X3受体有选择性作用,在该ATP浓度下Purotoxin-1P2X2和杂化二聚体P2X2/3并无激动作用。

Purotoxin-1对疼痛的潜在治疗作用。

 

其它膜受体通道(Others)

Smartox Biotechnology还提供其他类型的膜受体抑制剂:

Toxin name

Catalog#

Target

Morphiceptin

011CAS001

Agonist of µ-opoid receptors

Lys-conopressin G

11CON14

Vasopressin-like peptide

GsMTx4

08GSM001

Mechano sensitive ion channels

Obtustatin

10OBT001

Blocks the binding of α1β1 integrin to collagen IV

Rho-Conotoxin TIA

CON022

Blocks α1-adrenergic receptor



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