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Monoclonal Antibody to Human Factor B (Bb) (neo)
品牌:Quidel
货号:A712
规格:A712
货期:Quidel

品牌:Quidel 货号:A712 品名:Monoclonal Antibody to Human Factor B (Bb) (neo) 规格:100ul 这种单克隆抗体是针对纯化的人因子 B 产生的。它对在因子 B 的 Bb 结构域上表达的抗原具有特异性。它对因子 B 的 Bb 片段具有反应性,但对因子 B 本身没有反应。该抗体在体外抑制因子 B 的功能。

商品详情 参考文献 相关资料

产品介绍

Monoclonal Antibody to Human Factor B (Bb) (neo)

 货号

 A712 

规格

100uL 

蛋白质浓度

 > 1.0 mg/mL

纯度

 ≥ 95% by SDS PAGE

缓冲液

 Borate Buffered Saline (pH 8.4 ± 0.2)

同种型

  IgG2ak

背景

 Factor B is one of the complement proteins which is unique to the Alternative Pathway. It is a single-chain glycoprotein with a molecular weight of approximately 98 kD. The concentration of Factor B in human serum/plasma is ~200 μg/mL.

The Alternative Complement Pathway provides innate protection against microbial agents in the absence of specific antibodies. The activation of this complement pathway can be triggered by a variety of substances, including microbial polysaccharaides or lipids, gram-negative bacterial lipopolysaccharides, and surface determinants present on some viruses, parasites, virally infected mammalian cells, and cancer cells. In autoimmune diseases, the Alternative Complement Pathway may contribute directly to tissue damage. 


A centrally important reaction that occurs during alternative pathway activation is the conversion of the 93 kD molecular weight Factor B zymogen to an active proteolytic enzyme. This is accomplished in a two-step reaction. During the first reaction step, Factor B forms a magnesium-dependent complex with C3(H2O) or C3b. The C3(H2O),B complex is formed only in fluid phase, while the C3b,B complex can be formed either in fluid phase or on a target surface. Factor B, present in either complex, is cleaved into the Ba (33 kD) and Bb (60 kD) fragments in the second reaction step by the Alternative Pathway enzyme, Factor D. The C3b,Bb bimolecular complex constitutes the C3 convertase enzyme of the Alternative Pathway, while the Ba fragment is released into the fluid phase

应用

 

特异性

The specificity of the monoclonal antibody for the Factor B (Bb) protein was established by ELISA. The antibody binds a specific neoantigen in the Bb domain of native Factor B. It recognizes the Bb fragment of Factor B, but not native Factor B protein, or the Ba fragment of Factor B. 

物种交叉反应

 None tested

储存

≤30 Days 2°C to 8°C 

> 30 Days ≤ –20°C 

 

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