Caused by one of four closely related virus serotypes of the genus Flavivirus, family Flaviviridae, each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. In cell culture experiments and mice Morpholino antisense oligos have shown specific activity against Dengue virus.
The E.coli derived recombinant 15kDa protein is genetically engineered peptide which is derived from C terminus of Dengue Type-1 envelope. The expressed protein contains neutralizing epitopes and receptor binding domain, it has been used in the study for vaccine development. A 6 x His Tag is fused at its C-terminus.
Escherichia Coli.
Purified by proprietary chromatographic technique.
Protein is >95% pure as determined by 10% PAGE (coomassie staining).
1xPBS pH 7.4 and 0.02% sodium nitrate.
Dengue Envelope-ST1 D-III although stable at 4°C for 1 week, should be stored below
-18°C.
Please prevent freeze thaw cycles.
Each laboratory should determine an optimum working titer for use in its particular application.
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