Catalogue number
PRO-482
Synonyms
Zinc finger, C4H2 domain containing, HCA127, KIAA1166,
WWS, Hepatocellular Carcinoma-Associated Antigen 127, WRWF, Zinc Finger C4H2
Domain-Containing Protein.
Introduction
ZC4H2
(Zinc Finger, C4H2 Domain Containing) belongs to the zinc finger
domain-containing protein family. ZC4H2 has a C-terminal zinc finger domain which
is characterized by four cysteine residues and two histidine residues, and it also includes a coiled-coil
region. In addition, ZC4H2 has been detected as an autoantigen in
hepatocellular carcinoma patients. ZC4H2 has been identified as a potential
candidate for X-linked mental retardation. Among the diseases associated with
ZC4H2 are wieacker-wolf syndrome, and hepatocellular carcinoma.
Description
ZC4H2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 247 amino acids (1-224 a.a) and having a molecular mass of 28.6kDa.
ZC4H2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
ZC4H2 protein solution (0.25mg/ml) containing 20mM
Tris-HCl(pH 8.5), 50% glycerol, 0.2M NaCl and 2mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMADEQEI MCKLESIKEI RNKTLQMEKI KARLKAEFEA LESEERHLKE YKQEMDLLLQ EKMAHVEELR LIHADINVME NTIKQSENDL NKLLESTRRL HDEYKPLKEH VDALRMTLGL QRLPDLCEEE EKLSLDYFEK QKAEWQTEPQ EPPIPESLAA AAAAAQQLQV ARKQDTRQTA TFRQQPPPMK ACLSCHQQIH RNAPICPLCK AKSRSRNPKK PKRKQDE.
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
