Catalogue number
PRO-2228
Synonyms
UBQLN2,
Ubiquilin 2, CHAP1, PLIC2, Protein Linking IAP With Cytoskeleton 2,
Ubiquitin-Like Product Chap1/Dsk2, ALS15, N4BP4, NEDD4 Binding Protein 4,
Nedd4 Binding Protein 4, DSK2 Homolog, Ubiquilin-2, HRIHFB2157, HPLIC-2,
PLIC-2, DSK2.
Introduction
Ubiquilin-2, also known as UBQLN2 contains an N-terminal ubiquitin-like
domain and a C-terminal ubiquitin-associated domain. UBQLN2 is physically
linked with proteasomes as well as ubiquitin ligases, and therefore is
considered to functionally connect the ubiquitination machinery to the
proteasome in order to affect in vivo protein degradation. Furthermore, UBQLN2
binds the ATPase domain of the Hsp70-like Stch protein. Among the diseases which
are associated with UBQLN2: Amyotrophic lateral sclerosis 15, with or without
frontotemporal dementia as well as Amyotrophic lateral sclerosis type 15.
Description
UBQLN2 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 647 amino acids (1-624 a.a) and
having a molecular mass of 68.1kDa. UBQLN2 is fused to a 23 amino acid His-tag
at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
UBQLN2 protein solution (0.25mg/ml) containing Phosphate
Buffered Saline (pH7.4), 20% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater
than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMAENGES SGPPRPSRGP
AAAQGSAAAP AEPKIIKVTV KTPKEKEEFA VPENSSVQQF KEAISKRFKS QTDQLVLIFA GKILKDQDTL
IQHGIHDGLT VHLVIKSQNR PQGQSTQPSN AAGTNTTSAS TPRSNSTPIS TNSNPFGLGS LGGLAGLSSL
GLSSTNFSEL QSQMQQQLMA SPEMMIQIME NPFVQSMLSN PDLMRQLIMA NPQMQQLIQR NPEISHLLNN
PDIMRQTLEI ARNPAMMQEM MRNQDLALSN LESIPGGYNA LRRMYTDIQE PMLNAAQEQF GGNPFASVGS
SSSSGEGTQP SRTENRDPLP NPWAPPPATQ SSATTSTTTS TGSGSGNSSS NATGNTVAAA NYVASIFSTP
GMQSLLQQIT ENPQLIQNML SAPYMRSMMQ SLSQNPDLAA QMMLNSPLFT ANPQLQEQMR PQLPAFLQQM
QNPDTLSAMS NPRAMQALMQ IQQGLQTLAT EAPGLIPSFT PGVGVGVLGT AIGPVGPVTP IGPIGPIVPF
TPIGPIGPIG PTGPAAPPGS TGSGGPTGPT VSSAAPSETT SPTSESGPNQ QFIQQMVQAL AGANAPQLPN
PEVRFQQQLE QLNAMGFLNR EANLQALIAT GGDINAAIER LLGSQPS.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
