Catalogue number
PRO-2208
Synonyms
SERPINB4,
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member, Squamous Cell
Carcinoma, Antigen, SCCA2, Serine (Or Cysteine) Proteinase Inhibitor, Clade B
(Ovalbumin), Member, Peptidase Inhibitor, LEUPIN, SCCA, PI11, Protease
Inhibitor (Leucine-Serpin) Squamous Cell Carcinoma Antigen, SCCA2/SCCA1 Fusion
Protein, Serpin B4, SCCA1 PI-11.
Introduction
Serpin Peptidase Inhibitor, Clade B Member 4, also known as SERPINB4 is
a member of the serpin family. SERPINB4 acts as a protease inhibitor to
modulate the host immune response against tumor cells. Among the diseases associated
with SERPINB4 are: inverted papilloma as well as burns.
Description
SERPINB4 Human Recombinant produced in E.Coli is a
single, non-glycosylated polypeptide chain containing 413 amino acids (1-390 a.a)
and having a molecular mass of 47.2kDa.
SERPINB4 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile filtered colorless solution.
Formulation
SERPINB4 protein solution (0.5mg/ml) containing Phosphate
buffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater
than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMEDLCVA NTLFALNLFK HLAKASPTQN LFLSPWSISS TMAMVYMGSR GSTEDQMAKV LQFNEVGANA VTPMTPENFT SCGFMQQIQK GSYPDAILQA QAADKIHSSF RSLSSAINAS TGNYLLESVN KLFGEKSASF REEYIRLCQK YYSSEPQAVD FLECAEEARK KINSWVKTQT KGKIPNLLPE GSVDGDTRMV LVNAVYFKGK WKTPFEKKLN GLYPFRVNSA QRTPVQMMYL REKLNIGYIE DLKAQILELP YAGDVSMFLL LPDEIADVST GLELLESEIT YDKLNKWTSK DKMAEDEVEV YIPQFKLEEH YELRSILRSM GMEDAFNKGR ANFSGMSERN DLFLSEVFHQ AMVDVNEEGT EAAAGTGGVM TGRTGHGGPQ FVADHPFLFL IMHKITNCIL FFGRFSSP.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
