Catalogue number
CYT-982
Synonyms
Tumor
Necrosis Factor Receptor Superfamily Member 13B, Tumor Necrosis Factor Receptor
Superfamily, Member 13B, Transmembrane Activator And CAML Interactor ,TACI ,
Tumor Necrosis Factor Receptor 13B, CD267 Antigen, TNFRSF14B, CD267, CVID2, IGAD2,
CVID, RYZN.
Introduction
TNFRSF13B (TACI) is a transmembrane receptor protein found predominantly on the surface of B cells (a significant part of the immune system). TACI was at first discovered owing to its ability to interact with calcium-modulator and cyclophilin ligand (CAML). Later on, it was found that TACI plays a key role in humoral immunity by interacting with two members of the TNF family. Also, TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis.
Description
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TACI produced in Sf9 Insect
cells is a single, glycosylated polypeptide chain containing 407 amino acids
(1-165a.a.) and having a molecular mass of 45.8kDa (Molecular size on SDS-PAGE
will appear at approximately 25-50kDa).
TACI is expressed with a
242 amino acid hIgG-His tag at C-Terminus and purified by proprietary
chromatographic techniques.
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Source
Sf9,
Insect cells.
Physical Appearance
Sterile
filtered colorless solution.
Formulation
TACI
a protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4), 30%
glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater
than 90.0% as determined by SDS-PAGE.
Amino acid sequence
ADLMSGLGRS RRGGRSRVDQ
EERFPQGLWT GVAMRSCPEE QYWDPLLGTC MSCKTICNHQ SQRTCAAFCR SLSCRKEQGK FYDHLLRDCI SCASICGQHP
KQCAYFCENK LRSPVNLPPE LRRQRSGEVE NNSDNSGRYQ GLEHRGSEAS PALPGLKLSA DQVALVYSLE
PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN
AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD
ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS
VMHEALHNHY TQKSLSLSPG KHHHHHH.
Safety Data Sheet
Usage
ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
