Catalogue number
PRO-2353
Synonyms
Reticulon 4 Receptor, Nogo-66 Receptor, Nogo Receptor,
NOGOR, NGR , Reticulon-4 Receptor, UNQ330/PRO526.
Introduction
Reticulon
4 Receptor, also known as RTN4R, plays a role as a receptor for RTN4, OMG and
MAG. RTN4R is a glycosylphosphoinositol (GPI)-anchored protein which is a part
from the Nogo recptor family. RTN4R is expressed mainly in neurons and their
axons and is regulates axonal regeneration and plasticity in the ***** central
nervous system. RTN4R is a potential drug target for treating various
neurological cases such as spinal cord injury, CNS lesions, stroke and
Alzheimer's disease.
Description
RTN4R produced in Sf9 Baculovirus cells is a single,
glycosylated polypeptide chain containing 429 amino acids (27-447 a.a.) and
having a molecular mass of 46.3kDa (Molecular size on SDS-PAGE will appear at
approximately 40-57 kDa). RTN4R is expressed with a 8 amino acid His tag at
C-Terminus and purified by proprietary chromatographic techniques.
Source
Sf9, Baculovirus cells.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
RTN4R protein solution (0.5mg/ml) contains Phosphate
Buffered Saline (pH 7.4) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater
than 90.0% as determined by SDS-PAGE.
Amino acid sequence
CPGACVCYNE PKVTTSCPQQ GLQAVPVGIP AASQRIFLHG NRISHVPAAS
FRACRNLTIL WLHSNVLARI DAAAFTGLAL LEQLDLSDNA QLRSVDPATF HGLGRLHTLH LDRCGLQELG
PGLFRGLAAL QYLYLQDNAL QALPDDTFRD LGNLTHLFLH GNRISSVPER AFRGLHSLDR LLLHQNRVAH VHPHAFRDLG RLMTLYLFAN NLSALPTEAL APLRALQYLR
LNDNPWVCDC RARPLWAWLQ KFRGSSSEVP CSLPQRLAGR DLKRLAANDL QGCAVATGPY HPIWTGRATD
EEPLGLPKCC QPDAADKASV LEPGRPASAG NALKGRVPPG DSPPGNGSGP RHINDSPFGT LPGSAEPPLT AVRPEGSEPP GFPTSGPRRR PGCSRKNRTR SHCRLGQAGS
GGGGTGDSEG SLEHHHHHH.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
