Catalogue number
PRO-1744
Synonyms
Ectodysplasin A2 Receptor, XEDAR, TNFRSF27, EDA-A2 Receptor, X-Linked Ectodysplasin-A2 Receptor, EDAA2R, EDA-A2R, Tumor Necrosis Factor Receptor Superfamily Member 27, Tumor Necrosis Factor Receptor Superfamily Member XEDAR, EDAR2.
Introduction
EDA2R (ectodysplasin A2 receptor) mediates the activation of the
NF-kappa-B and JNK pathways. Activation seems to be mediated through binding to
TRAF3 and TRAF6. In addition, Mutations in EDA give rise to a clinical syndrome
characterized by loss of hair, sweat glands, and teeth. EDA2R specifically
binds to EDA-A2 isoform. This protein is a type III transmembrane protein of
the TNFR (tumor necrosis factor receptor) superfamily, and contains 3
cysteine-rich repeats and a single transmembrane domain however it lacks an
N-terminal signal peptide. Alternatively spliced transcript variants have been found
for this gene. Among the diseases associated with EDA2R are ectodermal
dysplasia 1, hypohidrotic, x-linked, and hypohidrotic ectodermal dysplasia.
Description
EDA2R Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 161 amino acids (1-138 a.a) and having a molecular mass of 17.7kDa.
EDA2R is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
EDA2R protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMDCQENE YWDQWGRCVT CQRCGPGQEL SKDCGYGEGG DAYCTACPPR
RYKSSWGHHR CQSCITCAVI NRVQKVNCTA TSNAVCGDCL PRFYRKTRIG GLQDQECIPC TKQTPTSEVQ
CAFQLSLVEA DAPTVPPQEA T
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
