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PerCP - anti mouse CD357 - Clone DTA-1
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PerCP - anti mouse CD357 - Clone DTA-1
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PerCP - anti mouse CD357 - Clone DTA-1
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PerCP - anti Mouse CD357 - DTA-1

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103,00 € tax excl.

265,00 € tax excl.

Product Description

  • DTA-1
  • Rat IgG2b
  • Flow Cytometry
  • PerCP
  • 0.2 mg/ml
  • Mouse CD25+ CD4+ T Cell Line
  • Mouse
  • The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
  • RUO
  • Liquid
  • Store in the dark at 2-8 °C
Mouse PU-PP-B Vial View larger
  • Mouse PU-PP-B Vial
  • Mouse PU-PP-B Vial

CD357 (GITR; glucocorticoid-induced TNFR-related gene) is a member of the TNF receptor superfamily, also known as TNFRSF18 and AITR (in humans). It is expressed at low levels on resting T lymph ocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-?B activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
  • Glucocorticoid-induced TNFR -related gene, TNFRSF18
  • 70 kD
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