品牌：List Labs 

货号：172B

品名：List Labs Anthrax Lethal Factor (LF), Recombinant from B. anthracis

中文名：

规格：1 mg

纯度：请参阅CoA

形式：请参阅CoA

储存温度：请参阅CoA

描述：

Bacillus anthracis is regarded as a major biological warfare threat. The principal virulence factors are a γ-linked poly-D-glutamic acid (PGA) capsule and a three component exotoxin composed of protective antigen (PA), lethal factor (LF) and edema factor (EF). These proteins act in binary combinations. The complex of PA, the cell binding component, with the LF enzyme, is termed lethal toxin and can cause death.  PA and the enzymatic EF together cause skin edema. Secreted PA is cleaved by membrane peptidases. This allows the 63 kDa carboxy terminal fragment to oligomerize to a heptamer or higher. Cleavage of PA is an essential step in exposing the binding sites for EF and LF. The complex enters the cell through endocytosis.  PA mediates the transfer of LF and EF to the cytoplasm where these enzymes recognize and alter their targets.

注：产品仅用于研究目的，不得用于人体或作为诊断剂。