Dysferlin antibody detects endogenous levels of total Dysferlin. DYSF Key calcium ion sensor involved in the Ca (2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Belongs to the ferlin family. Interacts with CACNA1S. Interacts with ANXA1; the interaction is Ca (2+)- and injury state-dependent.

Target	Dysferlin
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB
Recommended dilutions	WB: 1/500 - 1/3000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	A synthesized peptide derived from human Dysferlin.
Purification	Affinity Chromatography.
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	240 kDa
Swiss Prot	O75923
Buffer	Rabbit IgG in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.