VDR Antibody is a Rabbit Polyclonal antibody against VDR. The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factorsUpon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene productsIt is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effectsDownstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancerDefects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A)A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperpaRathyroidismMost patients have total alopecia in addition to ricketsThis antibody is a rabbit polyclonal antibody to human VDR.

Target	VDR
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB, IHC
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Purification	Affinity purified.
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot	P11473
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.