The antigen is a single chain transmembrane glycoprotein of molecular mass 67 kDa expressed on monocytes, myeloid progenitor cells and myeloid leukaemias. The antigen has homology with CD22 and myelin associated glycoprotein. CD33 appears very early on myelomonocytic precursors and is expressed in both the myeloid and monocytic cell lineages. CD33 is absent from pluripotent stem cells but appears on myelomonocytic precursors after CD34. It then continues to be expressed on both the myeloid and monocyte lineages

Target	CD33
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Tested Applications	FCM
Recommended dilutions	FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	CD33-Fc recombinant protein.
Purification	Affinity Chromatography
Form	Liquid
Isotype	IgG1
Conjugation	APC
Specificity	CD33 is a 67 kD type I transmembrane glycoprotein also known as Siglec-3, gp67, and p67. It is a sialoadhesion immunoglobulin superfamily member expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes and hematopoietic stem cells. CD33 functions as a sialic acid-dependent cell adhesion molecule with carbohydrate/lectin binding activity.
Storage	Store in the dark at 2-8 °C.
Molecular Weight	67 kDa
Swiss Prot	P20132
GeneID	945
Buffer	The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Availability	Shipped within 3-5 working days.
Note	This product is for research use only.