Distemper virus Fusion glycoprotein F0 Antibody is a Rabbit Polyclonal antibody against Distemper virus Fusion glycoprotein F0. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis.

Target	Distemper virus Fusion glycoprotein F0
Reactivity	Virus
Host	Rabbit
Clonality	Polyclonal
Tested Applications	ELISA, WB
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Recombinant Canine distemper virus Fusion glycoprotein F0 protein (136-608 AA)
Purity	> 95%
Purification	Purified by Protein G chromatography.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot	P12569
Buffer	0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.