GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells.  It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes.  GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells.  The human and murine molecules are species-specific and exhibit no cross-species reactivity.  Recombinant Rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Granulocyte-Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-α

AA Sequence: MAPTRSPNPV TRPWKHVDAI KEALSLLNDM RALENEKNED VDIISNEFSI QRPTCVQTRL KLYKQGLRGN LTKLNGALTM IASHYQTNCP PTPETDCEIE VTTFEDFIKN LKGFLFDIPF DCWKPVQK

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse FDC-P1 cells. The expected ED₅₀ is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁸ units/mg.