Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2).  Originally identified as a hypothalamic neuropeptide, nesfatin-1 is also expressed in other areas of the brain, in pancreatic islets β-cells, gastric endocrine cells, and adipocytes.  Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner.  Recombinant Human Nesfatin-1 is a 9.7 kDa protein containing 82 amino acid residues.

Source: E.coli

Synonyms: None

AA Sequence: VPIDIDKTKV QNIHPVESAK IEPPDTGLYY DEYLKQVIDV LETDKHFREK LQKADIEEIK SGRLSKELDL VSHHVRTKLD EL

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by an in vivo assay using healthy wild type male mice (C57BL/6J).  Mice were treated via intraperitoneal injection once at a dose of 4μg Nesfatin-1/gm of body weight.  Significant effects on body weight and food consumption were observed relative to saline-treated controls.

Note:

100μg is the largest vial size for this product.
Larger sizes supplied as multiple 100μg vials.