FGF-acidic is one of 23 known members of the FGF family.  Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation.  FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells.  FGF-acidic has the ability to signal through all the FGF receptors.  Recombinant Rat FGF-acidic is a 15.9 kDa protein consisting of 141 amino acid residues.

Source: E.coli

Synonyms: Fibroblast Growth Factor-acidic, FGF-1, HBGF-1, ECGF-beta

AA Sequence: MFNLPLGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SAGEVYIKGT ETGQYLAMDT EGLLYGSQTP NEECLFLERL EENHYNTYTS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cell proliferation assay using balb/c 3T3 cells.  The expected ED₅₀ is ≤ 0.1 ng/ml, in the presence of 10 µg/ml heparin, corresponding to a specific activity of ≥ 1 x 10⁷ units/mg.

Note:

1mg will be provided as 2x500μg.