Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells.  Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3.  Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation.  Unlike SCF, Flt3-Ligand exerts no activity on mast cells.  Multiple isoforms of Flt3-Ligand have been identified.  The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.).  The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform.

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AA Sequence: MTQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Source: E.coli