Product Description

Human Thrombin Activatable Fibrinolysis Inhibitor

Thrombin Activatable Fibrinolysis Inhibitor (TAFI), also known as plasma procarboxypeptidase-B and carboxypeptidase-U, is a single chain glycoprotein that is cleaved by thrombin, plasmin and trypsin. TAFI is purified from normal human plasma using immunoaffinity and ion-exchange chromatography. Activated TAFI cleaves C-terminal lysines on fibrin and cell surfaces resulting in down-regulation of fibrinolysis by reducing the number of plasminogen and tPA s on fibrin.