Product Description

Human PAI-1 Stable Mutant NBD Labeled at the Scissile Bond of the Reactive Loop

Mutagenesis of the P1' methionine residue (Met347) at the P1-P1' scissile bond of human PAI-1 stable mutant (K154T, Q319L, M354I and N150H) to cysteine followed by incorporation of NBD has produced a reporter PAI-1 with extended half life. The properties of this interesting new reagent have not been fully characterized.