In this special TentaGel® resin the PEG spacer is attached to the polystyrene/DVB matrix by a cleavable linkage. Therefore, the PEGylated compound can easily be cleaved and separated from the insoluble support. This can be achieved with either 10 mL/g of TFA/thioanisole (95:5) for 12 hours at room temperature, or with 10 mL/g of TFA/trimethylsilyl bromide/thioanisole (94:1:5) for 1 hour at room temperature.

TentaGel® is a gelatinous resin, an important support for solid phase synthesis. TentaGel® resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. Even less soluble peptides may be completely solubilized with this linker. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. (90 µm) 0.2-0.25 meq/g