Tenovin-1 is an inhibitor of sirtuins 1 and 2 (SIRT1/2) that also indirectly activates p53; sirtuins are considered class III histone deacetylases (HDACs). Tenovin-1 exhibits anticancer potential, increasing FOXO3 and p53 expression and inducing apoptosis in cutaneous T-cell lymphoma cells.
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