A styrylquinazoline derivative that acts as a p53 stabilizing agent. It not only restores p53 functions in mutant p53-expressing cells but can also significantly increase the protein level and promote the activity of wild-type p53 in multiple human cancer cell lines, leading to cell cycle arrest or apoptosis. CP-31398 enhances the protein levels of wild-type p53 by blockade of ubiquitination and degradation of p53 without interrupting the physical association between p53 and MDM2 in vivo.

Additional Information

Synonyms	N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine Dihydrochloride
Product #	C-2270
CAS #	259199-65-0
Chemical Name	N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine Dihydrochloride
Formula	C22H26N4O.2HCl
MW	435.39
Appearance	Yellow Solid
Purity	98% by TLC
Solubility	Soluble in H2O (25 mg/ml) or DMSO (5 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	CP 31398 dihydrochloride restores mutant p53 tumor suppressor function and inhibits UVB-induced skin cancer

Additional Information

MDL Number	MFCD11519956
ChemACX	X1763944-2
InChI	InChI=1S/C22H26N4O.2ClH/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H/b14-11+;;
SMILES	CN(C)CCCNC1=NC(=NC2=CC=CC=C21)/C=C/C3=CC=C(C=C3)OC.Cl.Cl