Sinefungin (58944-73-3) is a nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferases) inhibitor. IC50 < 1.0 and 2.5 μM for PRMT1 and SET7/9, respectively. Sinefungin binds with greater affinity to the adenine-specific DNA methyltransferase M.TaqI than S-adenosyl-L-homocysteine. Inhibits biofilm formation by Streptococcus pneumoniae.
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