A synthetic peptide inhibitor that inhibits caspase-4 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Additional Information

Synonyms	Z-LEVD-FMK, Caspase-4 Inhibitor (fluoromethylketone)
Product #	C-2244
Chemical Name	Z-LEVD-FMK, Caspase-4 Inhibitor (fluoromethylketone)
Formula	C31H45FN4O10
MW	652.7
Appearance	Liquid
Purity	95% by HPLC
Storage Temp	-20°C

Additional Information

MDL Number	MFCD08703607
InChI	InChI=1S/C31H45FN4O10/c1-18(2)14-23(35-31(43)46-17-20-10-8-7-9-11-20)29(41)33-21(12-13-25(38)44-5)28(40)36-27(19(3)4)30(42)34-22(24(37)16-32)15-26(39)45-6/h7-11,18-19,21-23,27H,12-17H2,1-6H3,(H,33,41)(H,34,42)(H,35,43)(H,36,40)
SMILES	CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
Peptide Sequence	Z-LEU-GLU(OME)-VAL-ASP(OME)-FMK