Bacitracin is a unique cyclic polypeptide antibiotic produced by Bacillus subtilis.  

Bacitracin is comprised of numerous antimicrobial peptide fractions. Notable fractions include A, A1, B, B1, B2, C, D, E, F, G, and X. Standard grade bacitracin (B002) is a mixture of these fractions. Bacitracin A has been found to have the most antibacterial activity. Bacitracins B1 and B2 together have a similar antibacterial potency (approx. 90% of bacitracin A). Other bacitracin fractions including bacitracin F and bacitracin Xa have not been studied extensively; however, they appear to have negligible antibacterial activity.

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