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4-Bromo-A23187

品牌：AG Scientific

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规格：1 mg

货期：

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CAS:76455-48-6Formula:C29H36BrN3O6MW:602.5Appearance:SlightyellowcrystalsPurity:99%

商品详情参考文献相关资料

4-Bromo-A23187 is a halogenated analog and divalent ionophore of A23187. Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes. Studies conducted in quin-2-loaded thymic lymphocytes of rat, 4-Bromo-A23187 has shown to saturate Ca2+ sites. This activity of 4-Bromo-A23187 has been suggested to be identical to ionomycin. Affinity towards Zn2+ and Mn2+ transportation, has been used for investigating cell regulation by Zn2+ and Mn2+.

Additional Information

Synonyms	4-Bromocalcimycin,4-Bromo-antibiotic A23187, 4-Bromo-A23187, Calcium Ionophore
Product #	A-1130
CAS #	76455-48-6
Chemical Name	6-BROMO-5-(METHYLAMINO)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-TRIMETHYL-2-[(2S)-1-OXO-1-(1H-PYRROL-2-YL)PROPAN-2-YL]-1,7-DIOXASPIRO[5.5]UNDECAN-8-YL]METHYL]-1,3-BENZOXAZOLE-4-CARBOXYLIC ACID
Formula	C₂₉H₃₆BrN₃O₆
MW	602.5
Appearance	Slight yellow crystals
Purity	99%
Solubility	CH₂Cl₂: Clear, colorless solution at 10 mg/ml.
Melting Point	316-319 °C
Storage Temp	+4°C
Use	Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes

Additional Information

MDL Number	MFCD00077667
ChemACX	X1087576-2
InChI	InChI=1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1
SMILES	C[C@@H]1CC[C@]2([C@@H](C[C@H]([C@H](O2)[C@H](C)C(=O)c3ccc[nH]3)C)C)O[C@@H]1Cc4nc5c(o4)cc(c(c5C(=O)O)NC)Br

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