*Please inquire the availability for this product. Terrein is a polar, substituted dihydrocyclopentenone first reported by Raistrick and colleagues in the 1930s and subsequently found in a number of Aspergillus and Penicillium species. For many years the biological profile and mode of action of terrein was unstudied; however, recent research showed that terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation, followed by MITF down-regulation. Terrein also reduces human keratinocyte proliferation by inhibiting ERK and by decreasing the expression of cyclin B1 and Cdc2 complex.

Additional Information

Synonyms	(+) Terrein, NSC 291308
Product #	T-2611
CAS #	582-46-7
Formula	C8H10O3
MW	154.2
Appearance	Light tan solid
Purity	>95% by HPLC
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	Terrein is a bioactive fungal metabolite that has plant growth inhibition and antibacterial activities

Additional Information

MDL Number	MFCD09752761
InChI	InChI=1S/C8H10O3/c1-2-3-5-4-6(9)8(11)7(5)10/h2-4,7-8,10-11H,1H3/b3-2+/t7-,8+/m0/s1
SMILES	O=C1\C=C(\C=C\C)[C@H](O)[C@@H]1O