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Concanamycin A CAS 80890-47-7 induces of autophagy, inhibits vacuole acidific

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Concanamycin A CAS 80890-47-7 induces of autophagy, inhibits vacuole acidific

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CAS:80890-47-7Formula:C46H75NO14MW:866.1Appearance:WhiteSolid/LyophilisatePurity:>98%

商品详情参考文献相关资料

Concanamycin A is an antibiotic and a highly potent and specific cell-permeable inhibitor of V-ATPases that allows to rapidly inactivate this proton pump in living cells. Concanamycin A is more potent specific inhibitor than Bafilomycin A1. Inhibits the acidification of organelles includinglysosomes and the Golgi apparatus. Concanamycin A is reported to block cell surface expression of viral glycoproteins without affecting synthesis. Exhibits cytotoxic effects in a number of cell lines in a cell viability assay. Studies have shown that Concanamycin A can cause apoptosis in Human oral squamous carcinoma cells.

Applications:

Concanamycin A can be used for viral entry studies, it inhibites syncytium formation without affecting glycoprotein synthesis.

Additional Information

Synonyms	Folimycin, ConcA, CMA
Product #	C-1057
CAS #	80890-47-7
Chemical Name	[(2R,3S,4R,6R)-6-[(2S,4R,5S,6R)-2-[4-[(3E,5E,13E,15Z)-10-ETHYL-9,11-DIHYDROXY-2,16-DIMETHOXY-6,8,12,14-TETRAMETHYL-17-OXO-18-OXA-1-YL]-3-HYDROXYPENTAN-2-YL]-2-HYDROXY-5-METHYL-6-[(E)-PROP-1-ENYL]OXAN-4-YL]OXY-4-HYDROXY-2-METHYLOXAN-3-YL] CARBAMATE
Formula	C₄₆H₇₅NO₁₄
MW	866.1
Appearance	White Solid / Lyophilisate
Purity	>98%
Solubility	Soluble in DSMO
Storage Temp	-20°C. PROTECT FROM LIGHT!
Use	Concanamycin A is an antibiotic which is a specific inhibitor of vacuolar H+ ATPase.

Additional Information

MDL Number	MFCD00210037
ChemACX	X1088871-6
InChI	InChI=1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26-,27-,28-,29+,30+,31-,32+,33-,34-,35+,37-,38+,39+,40-,41-,42-,43-,46-/m1/s1
SMILES	CC[C@H]1[C@H]([C@@H](C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O

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