A synthetic peptide that irreversibly inhibits activity of caspase-8 and related caspases and blocks apoptosis. The inhibitor is designed as a methyl ester to enhance cell permeability. The conjugation with biotin allows detection of activated caspases in conjunction with avidin-tags. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Additional Information

Synonyms	Biotin-IETD-FMK, IETD-FMK, Biotin-
Product #	B-2204
Chemical Name	Biotin-IETD-FMK, IETD-FMK, Biotin-
Formula	C38H62FN7O12S
MW	860
Appearance	Liquid
Purity	95% by HPLC
Storage Temp	-20°C

Additional Information

ChemACX	X1835754-9
InChI	InChI=1S/C38H62FN7O12S/c1-6-21(2)32(44-29(50)14-8-7-11-17-40-28(49)13-10-9-12-27-34-25(20-59-27)43-38(56)46-34)36(54)41-23(15-16-30(51)57-4)35(53)45-33(22(3)47)37(55)42-24(26(48)19-39)18-31(52)58-5/h21-25,27,32-34,47H,6-20H2,1-5H3,(H,40,49)(H,41,54)(H,42,55)(H,44,50)(H,45,53)(H2,43,46,56)
SMILES	CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)CCCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2
Peptide Sequence	BIOTIN-ILE-GLUE(OME)-THR-ASP(OME)-FMK