An isoquinoline alkaloid that acts as an anticancer agent. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. It induces the most potent apoptosis in acute lymphoblastic leukemia (ALL) cells with both MDM2 overexpression and a wild-type (wt)-p53, whereas no pro-apoptotic effect was detected in ALL cells that were negative for MDM2 and wt-p53.

Additional Information

Synonyms	Natural Yellow 18, 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
Product #	B-2196
CAS #	633-65-8
Chemical Name	Natural Yellow 18, 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
Formula	C20H18ClNO4
MW	371.81
Appearance	Yellow to orange Solid
Purity	98% by TLC
Solubility	MeOH (50 mg/ml) or Water (~ 2 mg/ml)
Melting Point	193-196 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2

Additional Information

MDL Number	MFCD00011939
ChemACX	X1006388-4
InChI	InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;
SMILES	COc1ccc2cc-3[n+](cc2c1OC)CCc4c3cc5c(c4)OCO5.Cl