Extracellular domain of human TNFR1 (aa 1-211) is fused to the Fc portion of human IgG1. The recombinant fusion protein is produced in HEK 293T cells. Application: rhTNFR1:Fc fusion protein can be used to block TNF mediated lysis with an inhibitory activity in a concentration range of 10-50ng/ml. Crossreactivity: rhTNFR1:Fc interacts with mouse and human TNF. rhsTNF binds to TNFR1 and triggers various biological effects (including cell death).
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