SB-203580 is a pyridinyl imidazole which acts as a specific inhibitor of p38 MAP Kinase. SB-203580 does not inhibit the MAP kinase homologs JNK and p42 MAP kinase.

* Listed below are a few published articles demonstrating the use of our SB-203580. Inquire for a full list of references.

• A New Isoquinolinium Derivative, Cadein1, Preferentially Induces Apoptosis in p53-defective Cancer Cells with Functional Mismatch Repair via a p38-dependent Pathway, Eun Ryoung Jang, Minsook Ryu, et al. J. Biol. Chem. Jan 2010. 285: 2986 - 2995.
• Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis, Rachel Spokoini, Shlomit Kfir-Erenfeld, et al. Mol. Endocrinol. Jun 2010. 24: 1136 - 1150.
• Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling, Hadar Sharfi and Hagit Eldar-Finkelman. Am J Physiol Endocrinol Metab. Feb 2008. 294: E307 - E315.

Additional Information

Additional Information