Ready-to-use colorimetric substrate for caspase-2/Ich-1 and related caspases that recognize the amino acid sequence VDVAD. Caspase-2 and related caspase activity can be quantified by detection of free pNA after cleavage from the peptide substrate VDVAD-pNA at OD405 nm using a spectrophotometer or plate reader. The ready-to-use caspase substrate provides an economic alternative for researchers who perform large amount of caspase assays.

Additional Information

Synonyms	Ac-VDVAD-pNA, Caspase-2 Substrate, Colorimetric
Product #	C-2237
Chemical Name	Ac-VDVAD-pNA, Caspase-2 Substrate, Colorimetric
Formula	C29H41N7O12
MW	679.7
Appearance	Liquid
Purity	98% by HPLC
Storage Temp	-20°C
Use	Ac-VDVAD-pNA is a chromogenic substrate for caspase-2

Additional Information

MDL Number	MFCD01862575
ChemACX	X1206316-2
InChI	InChI=1S/C29H41N7O12/c1-13(2)23(31-16(6)37)29(46)34-20(12-22(40)41)27(44)35-24(14(3)4)28(45)30-15(5)25(42)33-19(11-21(38)39)26(43)32-17-7-9-18(10-8-17)36(47)48/h7-10,13-15,19-20,23-24H,11-12H2,1-6H3,(H,30,45)(H,31,37)(H,32,43)(H,33,42)(H,34,46)(H,35,44)(H,38,39)(H,40,41)/t15-,19-,20-,23-,24-/m0/s1
SMILES	C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)Nc1ccc(cc1)[N+](=O)[O-])NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)C
Peptide Sequence	AC-VAL-ASP-VAL-ALA-ASP-PNA