RHC-80267, an inhibitor of Diacylglycerol lipase (DAG lipase) that is required for 2-arachidonoyl glycerol (2AG) synthesis.
Eicosanoids are signaling molecules made by oxidation of 20-carbon fatty acids. Eicosanoids exercise influence over numerous signaling pathways, primarily in inflammation or immunity, but also, as messengers in the central nervous system.
References:
Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295. Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207. Konrad, R.J., et al. 1994. Biochemistry 33, 13284. Mason-Garcia, M., et al. 1992. Am. J. Physiol. 262, C1197. Balsinde, J., et al. 1991. J. Biol. Chem. 266, 15638.
Additional Information
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Synonyms | Rhc 80267, RHC-80267, Rg 80267, U 57908 |
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Product # | R-2527 |
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CAS # | 83654-05-1 |
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Formula | C20 H34 N4 O4 |
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MW | 394.6 |
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Appearance | Solid |
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Purity | >98% |
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Solubility | soluble in DMSO (9mg/ml) and 100% ethanol (25mg/ml) |
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Melting Point | 118-121°C |
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Storage Temp | Room Temperature |
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Additional Information
| MDL Number | MFCD00210844 |
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| ChemACX | X1192840-2 |
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| InChI | InChI=1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26) |
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| SMILES | C1CCC(=NOC(=O)NCCCCCCNC(=O)ON=C2CCCCC2)CC1 |
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