Piericidin A is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces sp. It is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds to ubiquinone (s). Piericidin A inhibits both mitochondrial and bacterial NADH-ubiquinone oxidoreductases, binding close to NUOD-NUOB interface.

Additional Information

Synonyms	Shaoguanmycin B, Antibiotic MT 1882-I, Antibioic SN 198E, Antibiotic IT 143D, Piericidin A1
Product #	P-1474
CAS #	2738-64-9
Chemical Name	2-[(2E,4E,7E,9S,10S,11E)-10-HYDROXY-3,7,9,11-TETRAMETHYLTRIDECA-2,4,7,11-TETRAENYL]-5,6-DIMETHOXY-3-METHYLPYRIDIN-4-OL
Formula	C25H37NO4
MW	415.6
Appearance	Pale yellow oil
Purity	95% by HPLC
Solubility	Soluble in water (>1 mg/ml) at 25 °C, ethanol, DMSO, DMF, and PBS pH 7.2.
Storage Temp	-20°C
Use	An antibiotic and a member of the Class I inhibitors that acts as an effective inhibitor of Complex I

Additional Information

MDL Number	MFCD01677956
ChemACX	X1378619-9
InChI	InChI=1S/C25H37NO4/c1-9-18(4)22(27)19(5)15-17(3)12-10-11-16(2)13-14-21-20(6)23(28)24(29-7)25(26-21)30-8/h9-11,13,15,19,22,27H,12,14H2,1-8H3,(H,26,28)/b11-10+,16-13+,17-15+,18-9+/t19-,22+/m0/s1
SMILES	CC=C(C)C(C(C)C=C(C)CC=CC(=CCc1c(c(c(c(n1)OC)OC)O)C)C)O