CAS:76958-67-3Formula:C19H22O8MW:378.375Appearance:SolidPurity:98%(HPLC)

商品详情参考文献相关资料

The resorcyclic acid lactone Hypothemycin isolated from Phoma sp. has antifuangal and anticancer activity.

Hypothemycin normalized the morphology and inhibited anchorage-independent growth of Ki-ras transformed normal rat kidney(NRK) cells with selectivity and potency comparable to or greater than that of the MEK inhibitor U0126. It is also potent and selective threonine/tyrosine-specific kinase.

Hypothemycin inhibits proliferation of mouse and human T-cells and modulates production of cytokines during T-cell activation. It facilitates the ubiquitinylation process of cyclin D1.

Product References

The Resorcylic Acid Lactone Hypothemycin Selectively Inhibits the Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase Pathway in Cells, Biol. Pharm, Hidesuke Fukazawa, 33(2) (2010)?
Gene for the Biosynthesis of the Fungal Polyketides Hypothemycin from Hypomyces subiculosus and Radicicol from Pochonia chlamydosporia, Microbiol, Christopher D. Reeves, et al., vol. 74, no. 16 (2008)
Semiynthesis and Cytotoxicity of Hypothemycin Analogues, ChemMedChem, Brian R.Hearn Dr., et al., vol. 2 (2007)

Additional Information

Product #	H-2403
CAS #	76958-67-3
Formula	C₁₉ H₂₂ O₈
MW	378.375
Appearance	Solid
Purity	98% (HPLC)
Solubility	Soluble in DMSO or acetone; insoluble in methanol or water
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Hypothemycin exhibits antifungal and cytotoxic activity against some tumor cell lines partly attributed to inhibition of Ras-inducible genes

Additional Information

ChemACX	X1867744-0
InChI	InChI=1S/C19H22O8/c1-9-4-3-5-12(20)17(23)14(22)8-15-18(27-15)11-6-10(25-2)7-13(21)16(11)19(24)26-9/h3,5-7,9,14-15,17-18,21-23H,4,8H2,1-2H3/b5-3-/t9-,14-,15+,17+,18+/m0/s1
SMILES	C[C@H]1C/C=CC(=O)[C@H]([C@H](C[C@@H]2[C@H](O2)C3=C(C(=CC(=C3)OC)O)C(=O)O1)O)O

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