HBTU is a commonly used coupling reagent, and can be used in solid phase peptide synthesis. It is reported to convert carboxylic acids into azides efficiently and practically. This process may be used with a wide range of carboxylic acids including N-protected amino acids. It has also been reported to be useful in one-pot synthesis of dipeptidyl urea esters, ureas, and carbamates from acids.

Additional Information

Synonyms	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate
Product #	H-2511
CAS #	94790-37-1
Formula	C11H16F6N5OP
MW	379.3
Appearance	Powder Solid
Purity	99%
Solubility	Soluble in water, acetonitrile (0.1 mg/ml), DMF, ethanol (slight), and acetone (slight).
Melting Point	200° C (lit.)(dec.)
Storage Temp	-20°C

Additional Information

SMILES	CN(C)C(=[N+](C)C)ON1C2=CC=CC=C2N=N1.F[P-](F)(F)(F)(F)F