*Please inquire the availability for this product. Platensimycin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Its discovery was heralded by high profile publication and commentary in the scientific and lay press. Platensimycin was discovered by a target-based, whole-cell screening strategy using an antisense differential sensitivity assay, based on the inhibition of fatty acid synthesis. Platensimycin inhibits bacterial growth by selectively inhibiting the elongation enzyme, b-ketoacyl acyl carrier protein synthase (FabF) of the fatty acid synthesis pathway.

Additional Information

Product #	P-2781
CAS #	835876-32-9
Formula	C24H27NO6
MW	441.2
Appearance	Light tan solid
Purity	>95% by HPLC
Solubility	Soluble in DMSO (20 mg/ml), ethanol (20 mg/ml), methanol, DMF, and water (poorly)
Melting Point	289.65 °C
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	Platensimycin is a novel, broad spectrum, Gram-positive antibiotic

Additional Information

MDL Number	MFCD14635440
InChI	InChI=1S/C24H27NO7/c1-22(7-6-17(28)25-18-14(26)4-3-13(19(18)29)21(30)31)16(27)5-8-24-10-12-9-15(20(22)24)32-23(12,2)11-24/h3-5,8,12,15,20,26,29H,6-7,9-11H2,1-2H3,(H,25,28)(H,30,31)/t12-,15+,20+,22-,23-,24+/m1/s1
SMILES	C[C@@]12C[C@]34C[C@H]1C[C@@H]([C@H]3[C@](C(=O)C=C4)(C)CCC(=O)Nc5c(ccc(c5O)C(=O)O)O)O2