Steffimycin B is a anthracycline metabolite isolated from a Streptomyces sp. displaying antibacterial and antineoplastic properties. Binding to DNA, crystallographic studies suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analogue was shown to be active against ras oncogene-expressed cells.

Additional Information

Synonyms	Antibiotic U 40615
Product #	S-2068
CAS #	54526-94-2
Chemical Name	3,10,12-TRIHYDROXY-2,8-DIMETHOXY-3-METHYL-4,6,11-TRIOXO-1,2,3,4,6,11-HEXAHYDRO-1-TETRACENYL 6-DEOXY-2,4-DI-O-METHYLHEXOPYRANOSIDE
Formula	C29H32O13
MW	588.6
Appearance	Orange Lyophilisate
Purity	99% by HPLC
Solubility	DMSO
Storage Temp	+4°C
Use	Steffimycin B is a anthracycline metabolite isolated from a Streptomyces sp. displaying antibacterial and antineoplastic properties

Additional Information

MDL Number	MFCD01713106
ChemACX	X6952277-8
InChI	InChI=1S/C29H32O13/c1-10-23(38-4)22(34)25(39-5)28(41-10)42-24-18-14(26(35)29(2,36)27(24)40-6)9-13-17(21(18)33)20(32)16-12(19(13)31)7-11(37-3)8-15(16)30/h7-10,22-25,27-28,30,33-34,36H,1-6H3
SMILES	CC1C(C(C(C(O1)OC2c3c(cc4c(c3O)C(=O)c5c(cc(cc5O)OC)C4=O)C(=O)C(C2OC)(C)O)OC)O)OC