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Bestatin (Ubenimix)
品牌:AG Scientific
货号:
规格:5 mg
货期:

CAS:58970-76-6Formula:C16H24N2O4MW:308.4Appearance:WhitesolidPurity:>98%byHPLC

商品详情 参考文献 相关资料

Bestatin is "pseudo"-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits antitumor activity and has been investigated in clinical trials. Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer1p>.

1.) Tsukamoto H, Shibata K, Kajiyama H, Terauchi M, Nawa A,Kikkawa F. 2008. Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer. BMC Cancer. 8:74.

 

Additional Information

SynonymsUbenimix, Inobestin, NK 421, Leukotriene A4 hydrolase, Aminopeptidase N
Product #B-2547
CAS #58970-76-6
FormulaC16H24N2O4
MW308.4
AppearanceWhite solid
Purity>98% by HPLC
SolubilitySoluble in water (<1 25), dmso (2 mg>
Melting Point233-236 °C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseBestatin is a potent aminopeptidase inhibitor use in cancer

Additional Information

MDL NumberMFCD00083262
InChIInChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
SMILESCC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](Cc1ccccc1)N)O
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