amlexanox induces the complete and reversible non-apoptotic inhibition of cell migration and proliferation, and although amlexanox does not induce either the down-regulation of F-actin levels or the depolymerization of actin filaments, it does induce the tyrosine phosphorylation of cortactin, a Src substrate known to regulate actin bundling.

 

 

1. L Koch Nat. Rev. Endocrinol. 2013 9:185

2. SM Reilly et al. Nat. Med. 2012 19:313

3. L Matteo et al. J.Biol.Chem 2000 275:32573