Potent and selective inhibitor of AKT or Protein Kinase B. AKT inhibitors evolved from adenosine triphosphate (ATP). AKT inhibitors have a potential clinical application in anti-cancer drug development . Weak inhibitor of phosphatidylinositol 3-kinase (PI3-K) (IC= 83 M). Has been shown to inhibit the growth of the following cancer cell lines: HeLa (IC= 2.5 M), HT-29 (IC= 10 M), MCF-7 (IC= 1.2 M), and PC-3 (IC= 2.0 M).
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